I had been using the Intellijel 1u Pedal I/O to use some guitar pedals I have as an fx loop, and then recently realized I could just ignore the send and plug my guitar in to the pedal chain and bring it into my rack via the return on the I/O. From there it can go pretty much anywhere. Sending it to Morphagene with a clocked record is pretty fun. It's like playing over a looper but more interesting.
On the output I am just including it with my rack's audio out into my computer's audio interface, so I haven't thought about bringing an amp into the equation yet. Sounds pretty good without one though. I've been considering getting a Strymon Iridium to add to my pedal chain, though since the rack is not dedicated to guitar alone (mixes in with VCOs and the rest) this is probably about as far as I'll go with it.